Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17069770 | 0.87 | BDKRB1 (0.43) | BDKRB1L3MBTL1PDK2HCRTR1HCRTR2 | |
| SCHEMBL18163349 | 0.82 | BDKRB1 (0.43) | BDKRB1L3MBTL1PDK2HCRTR1HCRTR2 | |
| SCHEMBL18594627 | 0.82 | PDK2 (0.42) | BDKRB1L3MBTL1RIPK1PDK2HCRTR1 | |
| SCHEMBL17071981 | 0.80 | L3MBTL1 (0.45) | BDKRB1L3MBTL1PDK2HCRTR1HCRTR2 | |
| SCHEMBL6900814 | 0.80 | NPC1 (0.52) | BDKRB1L3MBTL1PDK2HCRTR1HCRTR2 | |
| SCHEMBL20169431 | 0.79 | BDKRB1 (0.47) | BDKRB1L3MBTL1PDK2HCRTR1HCRTR2 | |
| SCHEMBL18594628 | 0.77 | HDAC4 (0.39) | RIPK1PDK2HCRTR1HCRTR2PLK1 | |
| SCHEMBL6902477 | 0.77 | HCRTR1 (0.49) | BDKRB1L3MBTL1HCRTR1HCRTR2NPC1 | |
| SCHEMBL6153221 | 0.72 | RIPK1 (0.51) | RIPK1NPC1RAB9ALMNATP53 | |
| SCHEMBL18195999 | 0.72 | L3MBTL1 (0.47) | BDKRB1L3MBTL1PDK2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975876-B2 | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-05-22 | — | — | US | disclosed |