Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11860696 | 0.78 | GAA (0.63) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL20169448 | 0.70 | NPC1 (0.42) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL3767544 | 0.70 | NPC1 (0.52) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL29235094 | 0.68 | NPC1 (0.61) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL23388916 | 0.68 | HTR2C (0.44) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL6675393 | 0.67 | PNP (0.40) | L3MBTL1MEN1KMT2A | |
| SCHEMBL92518 | 0.67 | L3MBTL1 (0.56) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL2539997 | 0.67 | NPC1 (0.67) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL4388005 | 0.67 | HTR2C (0.46) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10574468 | 0.67 | NPC1 (0.46) | GAANPC1RAB9AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975891-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-22 | — | — | US | disclosed |