Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1570950 | 0.92 | NPC1 (0.50) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL31252097 | 0.83 | NPC1 (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL11860696 | 0.81 | GAA (0.63) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7277648 | 0.81 | ALDH1A1 (0.45) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL2539997 | 0.81 | NPC1 (0.67) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL7284424 | 0.80 | ALDH1A1 (0.44) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8384325 | 0.79 | GAA (0.44) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL23163772 | 0.79 | SMN1; SMN2 (0.49) | NPC1RAB9AL3MBTL1SMN1; SMN2HTR2C | |
| SCHEMBL29235094 | 0.79 | NPC1 (0.61) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL25202798 | 0.79 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2HTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186232-B1 | P38 MAP KINASE INHIBITING INDANYL UREA COMPOUNDS | TORRENT PHARMACEUTICALS LTD (IN) | 2019-03-27 | — | — | EP | disclosed |
| US-9963463-B2 | Urea-substituted indanes as P38 map kinase inhibitors | TORRENT PHARMACEUTICALS LIMITED (IN) | 2018-05-08 | — | — | US | disclosed |
| US-9963463-B2 | Urea-substituted indanes as P38 map kinase inhibitors | TORRENT PHARMACEUTICALS LIMITED (IN) | 2018-05-08 | — | — | US | disclosed |
| US-8569313-B2 | Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| US-20100305090-A1 | META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2010-12-02 | — | — | US | disclosed |
| US-6403595-B1 | ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305090-A1 | META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS | MMP7, DNPEP, METAP1 | NPC1 3057/4885RAB9A 2590/4885L3MBTL1 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.