Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | PREP | P48147 | 3/20 | 0.46 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28946599 | 0.76 | PREP (0.53) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946630 | 0.76 | PREP (0.51) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946597 | 0.76 | PREP (0.53) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946632 | 0.76 | PREP (0.51) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946571 | 0.75 | TSHR (0.54) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946573 | 0.75 | TSHR (0.54) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946629 | 0.75 | SIGMAR1 (0.50) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL28946627 | 0.75 | SIGMAR1 (0.50) | TMEM97SIGMAR1PREPAADATNPSR1 | |
| SCHEMBL18134517 | 0.75 | IDO1 (0.47) | TSHRL3MBTL1LMNA | |
| SCHEMBL16730949 | 0.75 | IDO1 (0.47) | TSHRL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975888-B2 | Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug | MERCK SHARP & DOHME CORP. (US) | 2018-05-22 | — | — | US | disclosed |