Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654045 | 0.83 | NOS3 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL17833808 | 0.80 | RPS6KA3 (0.35) | — | |
| SCHEMBL12895995 | 0.79 | NOS3 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL18068087 | 0.76 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL23842580 | 0.74 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL18068017 | 0.74 | RPS6KA3 (0.38) | — | |
| SCHEMBL25927958 | 0.74 | NOS3 (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL20285917 | 0.74 | LMNA (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL13939587 | 0.74 | CYP3A4 (0.36) | — | |
| SCHEMBL12749936 | 0.74 | NOS3 (0.36) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975896-B2 | Inhibitors of transcription factors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-22 | — | — | US | disclosed |