Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.40 |
| ▸ | NPY1R | P25929 | 4/20 | 0.40 |
| ▸ | NPY4R | P50391 | 4/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21216267 | 0.92 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL24831385 | 0.92 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL17117123 | 0.92 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL21966951 | 0.92 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL19370650 | 0.91 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL25064729 | 0.91 | NPY5R (0.44) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL23515087 | 0.91 | SIRT2 (0.46) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL19370639 | 0.90 | SIRT5 (0.41) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL23385512 | 0.87 | FURIN (0.39) | FURINNPY5RNPY1RNPY4RNPY2R | |
| SCHEMBL25680283 | 0.86 | FURIN (0.40) | FURINSIRT5SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895513-B1 | FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION | GENZYME CORP (US) | 2018-05-23 | — | — | EP | disclosed |