Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.48 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509946 | 0.88 | OPRM1 (0.46) | OPRM1MRGPRX2L3MBTL1OPRK1OPRD1 | |
| SCHEMBL20170623 | 0.80 | OPRM1 (0.45) | OPRM1MRGPRX2L3MBTL1OPRK1OPRD1 | |
| SCHEMBL20170734 | 0.76 | OPRM1 (0.45) | OPRM1MRGPRX2OPRK1OPRD1LMNA | |
| SCHEMBL20170795 | 0.76 | OPRM1 (0.45) | OPRM1MRGPRX2OPRK1OPRD1LMNA | |
| SCHEMBL20170812 | 0.76 | OPRM1 (0.45) | OPRM1MRGPRX2OPRK1OPRD1LMNA | |
| SCHEMBL20170736 | 0.76 | OPRM1 (0.45) | OPRM1MRGPRX2OPRK1OPRD1LMNA | |
| SCHEMBL16509932 | 0.76 | OPRM1 (0.50) | OPRM1MRGPRX2L3MBTL1OPRK1OPRD1 | |
| SCHEMBL15685095 | 0.74 | OPRM1 (0.49) | OPRM1L3MBTL1OPRK1OPRD1 | |
| SCHEMBL12836599 | 0.72 | OPRM1 (0.47) | OPRM1MRGPRX2L3MBTL1OPRK1OPRD1 | |
| SCHEMBL12836844 | 0.72 | OPRM1 (0.47) | OPRM1MRGPRX2L3MBTL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |