Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170773 | 0.81 | OPRM1 (0.66) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL20170618 | 0.80 | OPRM1 (0.48) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL16509946 | 0.77 | OPRM1 (0.46) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| Thebacon SCHEMBL25766 | 0.73 | OPRD1 (0.63) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| Thebacon SCHEMBL1649199 | 0.73 | OPRD1 (0.63) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| Thebacon SCHEMBL29632752 | 0.73 | OPRD1 (0.63) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| Thebacon SCHEMBL21304123 | 0.73 | OPRD1 (0.63) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL12944986 | 0.73 | OPRM1 (0.51) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| Thebacon SCHEMBL6240045 | 0.73 | OPRD1 (0.62) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL18457702 | 0.73 | OPRM1 (0.51) | OPRM1OPRK1OPRD1MRGPRX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |