Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170714 | 1.00 | OPRM1 (0.51) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL20170797 | 0.86 | OPRM1 (0.55) | OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL20170720 | 0.86 | OPRM1 (0.55) | OPRM1OPRD1OPRK1CYP2D6 | |
| SCHEMBL20170852 | 0.86 | OPRM1 (0.53) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL13507183 | 0.78 | OPRM1 (0.52) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL16624837 | 0.76 | OPRM1 (0.51) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL22058076 | 0.75 | OPRM1 (0.52) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL16509927 | 0.75 | OPRM1 (0.52) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL12091238 | 0.74 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL13378892 | 0.74 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CYP2D6CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |