Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYBB | P04839 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170720 | 1.00 | OPRM1 (0.55) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 | |
| SCHEMBL20170668 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL20170714 | 0.86 | OPRM1 (0.51) | OPRM1OPRK1OPRD1CYP2D6 | |
| SCHEMBL20170766 | 0.86 | OPRK1 (0.53) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 | |
| SCHEMBL20170828 | 0.81 | OPRM1 (0.49) | OPRM1OPRK1OPRD1 | |
| SCHEMBL13575427 | 0.78 | OPRM1 (0.52) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 | |
| SCHEMBL19496310 | 0.78 | OPRM1 (0.52) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 | |
| SCHEMBL15858564 | 0.78 | OPRM1 (0.52) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 | |
| SCHEMBL20170699 | 0.75 | OPRM1 (0.41) | OPRM1OPRK1OPRD1 | |
| SCHEMBL16509927 | 0.74 | OPRM1 (0.52) | OPRM1OPRK1OPRD1CTDSP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |