Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12944957 | 1.00 | OPRM1 (0.42) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12944958 | 0.88 | OPRD1 (0.43) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL20170597 | 0.88 | OPRD1 (0.43) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12944959 | 0.84 | OPRM1 (0.39) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL20170803 | 0.83 | OPRM1 (0.35) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL20170782 | 0.76 | OPRD1 (0.44) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL18457639 | 0.76 | OPRD1 (0.49) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL17284793 | 0.76 | OPRD1 (0.55) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL12646372 | 0.76 | OPRD1 (0.55) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| SCHEMBL10222587 | 0.75 | GAA (0.39) | OPRD1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |