Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 5/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18458091 | 0.76 | OPRM1 (0.36) | MEN1HTTKMT2AAGTR2AGTR1 | |
| SCHEMBL21202021 | 0.70 | MEN1 (0.36) | MEN1HTTKMT2ABRD4CREBBP | |
| SCHEMBL12013639 | 0.67 | OPRM1 (0.36) | MEN1HTTKMT2AAGTR2AGTR1 | |
| SCHEMBL12646217 | 0.67 | OPRM1 (0.36) | MEN1HTTKMT2AAGTR2AGTR1 | |
| SCHEMBL12013637 | 0.67 | OPRM1 (0.51) | — | |
| SCHEMBL27924335 | 0.67 | OPRM1 (0.51) | — | |
| SCHEMBL22058857 | 0.66 | OPRM1 (0.37) | MEN1HTTKMT2AAGTR2AGTR1 | |
| SCHEMBL18458090 | 0.66 | GAA (0.44) | MEN1KMT2AAGTR2AGTR1BCHE | |
| SCHEMBL18474049 | 0.64 | MEN1 (0.37) | MEN1HTTKMT2AAGTR2AGTR1 | |
| SCHEMBL21300617 | 0.63 | BCHE (0.67) | BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |