Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | CYBB | P04839 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509927 | 0.88 | OPRM1 (0.52) | OPRK1OPRM1CYP2D6OPRD1CTDSP1 | |
| SCHEMBL22058076 | 0.88 | OPRM1 (0.52) | OPRK1OPRM1CYP2D6OPRD1CTDSP1 | |
| SCHEMBL19496310 | 0.88 | OPRM1 (0.52) | OPRK1OPRM1CYP2D6OPRD1CYBB | |
| SCHEMBL13575427 | 0.88 | OPRM1 (0.52) | OPRK1OPRM1CYP2D6OPRD1CYBB | |
| SCHEMBL15858564 | 0.88 | OPRM1 (0.52) | OPRK1OPRM1CYP2D6OPRD1CYBB | |
| SCHEMBL20170720 | 0.86 | OPRM1 (0.55) | OPRK1OPRM1CYP2D6OPRD1CYBB | |
| SCHEMBL20170797 | 0.86 | OPRM1 (0.55) | OPRK1OPRM1CYP2D6OPRD1CYBB | |
| SCHEMBL20170852 | 0.86 | OPRM1 (0.53) | OPRK1OPRM1CYP2D6OPRD1LMNA | |
| SCHEMBL12091238 | 0.85 | OPRM1 (0.54) | OPRK1OPRM1CYP2D6OPRD1CTDSP1 | |
| SCHEMBL13378892 | 0.85 | OPRM1 (0.54) | OPRK1OPRM1CYP2D6OPRD1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |