Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12944956 | 0.86 | OPRD1 (0.41) | OPRD1SIGMAR1OPRK1OPRM1CYP2D6 | |
| SCHEMBL20170803 | 0.73 | OPRM1 (0.35) | OPRD1SIGMAR1OPRK1OPRM1 | |
| SCHEMBL12944958 | 0.68 | OPRD1 (0.43) | OPRD1SIGMAR1OPRK1OPRM1CYP2D6 | |
| SCHEMBL12646221 | 0.66 | OPRD1 (0.48) | OPRD1SIGMAR1HCRTR1OPRK1OPRM1 | |
| SCHEMBL18473433 | 0.66 | OPRD1 (0.48) | OPRD1SIGMAR1HCRTR1OPRK1OPRM1 | |
| SCHEMBL22058341 | 0.66 | OPRD1 (0.48) | OPRD1SIGMAR1HCRTR1OPRK1OPRM1 | |
| SCHEMBL17284782 | 0.66 | OPRD1 (0.48) | OPRD1SIGMAR1HCRTR1OPRK1OPRM1 | |
| SCHEMBL18458097 | 0.66 | OPRD1 (0.48) | OPRD1SIGMAR1OPRK1OPRM1CYP2D6 | |
| SCHEMBL20170802 | 0.66 | OPRD1 (0.35) | OPRD1SIGMAR1OPRK1OPRM1CYP2D6 | |
| SCHEMBL20170876 | 0.65 | OPRM1 (0.36) | OPRD1SIGMAR1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |