Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28834772 | 0.91 | HPGD (0.54) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL6044463 | 0.88 | HSD17B10 (0.46) | HPGDLMNAPLK1SMN1; SMN2RAB9A | |
| SCHEMBL30077217 | 0.85 | HPGD (0.53) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL3569510 | 0.80 | HPGD (0.53) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL2796317 | 0.79 | PLK1 (0.74) | LMNAPLK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16002850 | 0.79 | PLK1 (0.52) | HPGDPLK1SMPD1RAB9ANPC1 | |
| SCHEMBL16000138 | 0.78 | MAOB (0.51) | HPGDSMN1; SMN2RAB9ANPC1MAOA | |
| SCHEMBL23957505 | 0.78 | HPGD (0.51) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL30257717 | 0.78 | HPGD (0.51) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL16015342 | 0.78 | LMNA (0.67) | HPGDLMNASMPD1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772480-B2 | HIV REPLICATION INHIBITOR | SHIONOGI & CO (JP) | 2020-12-09 | — | — | EP | disclosed |
| EP-2772480-B1 | HIV REPLICATION INHIBITOR | SHIONOGI & CO (JP) | 2018-05-23 | — | — | EP | disclosed |