Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 8/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057724 | 1.00 | ENPP2 (0.52) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL17045111 | 0.88 | ENPP2 (0.51) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL15550064 | 0.88 | ENPP2 (0.51) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL15549996 | 0.88 | ENPP2 (0.66) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL17045096 | 0.88 | ENPP2 (0.66) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL17053656 | 0.86 | ALDH1A1 (0.43) | ENPP2ALDH1A1MAPTHPGDKDM2B | |
| SCHEMBL17057704 | 0.86 | ENPP2 (0.52) | ENPP2LPAR1ALDH1A1MAPTHPGD | |
| SCHEMBL15553172 | 0.82 | ENPP2 (0.45) | ENPP2LPAR1SCN9ARORCAPP | |
| SCHEMBL15553173 | 0.82 | ENPP2 (0.45) | ENPP2LPAR1SCN9ARORCAPP | |
| SCHEMBL15550551 | 0.81 | APP (0.46) | ENPP2KDM2BCYP2A6APPCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877185-B1 | 2-(1-(1-(6-((CYCLOHEXYL)OXY)-5-(TRIFLUOROMETHYL)NAPHTHALEN-2-YL)ETHYL)PIPERIDIN-3-YL)ACETIC ACID DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATIONS AND AUTOIMMUNE DISORDERS | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |