Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1113912 | 0.86 | YTHDC1 (0.62) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL31373063 | 0.86 | YTHDC1 (0.62) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL16211705 | 0.85 | YTHDC1 (0.45) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL22833939 | 0.82 | YTHDC1 (0.55) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL9885008 | 0.81 | YTHDC1 (0.57) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL1114289 | 0.80 | PIK3CA (0.63) | FLT3PIK3CAMTORPIK3CG | |
| SCHEMBL935632 | 0.80 | YTHDC1 (0.59) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL29878593 | 0.80 | YTHDC1 (0.59) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL566733 | 0.80 | TP53 (0.61) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 | |
| SCHEMBL18123332 | 0.79 | YTHDC1 (0.51) | FLT3YTHDC1CYP2C19MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991987-B1 | PURINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |