Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | PI4KA | P42356 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.61 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.61 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.61 |
| ▸ | AHCY | P23526 | 4/20 | 0.54 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124747 | 0.87 | PI4KA (0.61) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL22833939 | 0.87 | YTHDC1 (0.55) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL17262848 | 0.87 | PI4KA (0.64) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL9885008 | 0.86 | YTHDC1 (0.57) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL10121595 | 0.85 | PI4KA (0.61) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL20275396 | 0.85 | YTHDC1 (0.69) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL935632 | 0.85 | YTHDC1 (0.59) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL29878593 | 0.85 | YTHDC1 (0.59) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL243515 | 0.85 | YTHDC1 (0.69) | TP53CYP2C9NFKB1MAPK1HSD17B10 | |
| SCHEMBL29354479 | 0.85 | YTHDC1 (0.69) | TP53CYP2C9NFKB1MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391694-B2 | Process for the preparation of 2-fluoroadenine | MERCK SHARP & DOHME LLC | 2025-08-19 | — | — | US | disclosed |
| US-20220242866-A1 | PROCESS FOR THE PREPARATION OF 2-FLUOROADENINE | MERCK SHARP & DOHME CORP. (US) | 2022-08-04 | — | — | US | disclosed |
| EP-3218377-B1 | ADENINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF ALLERGIC DISEASES OR OTHER INFLAMMATORY CONDITIONS | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2022-04-13 | — | — | EP | disclosed |
| US-10919894-B2 | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2021-02-16 | — | — | US | disclosed |
| WO-2020263660-A1 | PROCESS FOR THE PREPARATION OF 2-FLUOROADENINE | MERCK SHARP & DOHME CORP. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020263660-A1 | PROCESS FOR THE PREPARATION OF 2-FLUOROADENINE | MERCK SHARP & DOHME CORP. (US) | 2020-12-30 | — | — | WO | disclosed |
| US-20200223849-A1 | ADENINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF ALLERGIC DISEASES OR OTHER INFLAMMATORY CONDITIONS | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2020-07-16 | — | — | US | disclosed |
| US-10584125-B2 | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions | GLAXOSMITHKLINE BIOLOGICALS SA (BE) | 2020-03-10 | — | — | US | disclosed |
| US-20190038631-A1 | 6-AMINO-PURIN-8-ONE COMPOUNDS | GLAXOSMITHKLINE LLC | 2019-02-07 | — | — | US | disclosed |
| US-20190038631-A1 | 6-AMINO-PURIN-8-ONE COMPOUNDS | GLAXOSMITHKLINE LLC | 2019-02-07 | — | — | US | disclosed |
| EP-2324025-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | Smithkline Beecham Corporation (US) | 2011-05-25 | — | — | EP | disclosed |
| EP-2320905-A1 | NOVEL ADENINE DERIVATIVES | Smithkline Beecham Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| US-20100075995-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075995-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075995-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| WO-2010018130-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018134-A1 | NOVEL ADENINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018131-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018133-A1 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018132-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10584125-B2 | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions | HRH3, HRH4, HRH1 | TP53 2290/4885CYP2C9 1134/4885NFKB1 170/4885 |
| US-20190038631-A1 | 6-AMINO-PURIN-8-ONE COMPOUNDS | IFNG, IFNAR1, IRF3 | TP53 651/4885CYP2C9 3044/4885NFKB1 298/4885 |
| US-20200223849-A1 | ADENINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF ALLERGIC DISEASES OR OTHER INFLAMMATORY CONDITIONS | HRH3, HRH4, HRH1 | TP53 2303/4885CYP2C9 1164/4885NFKB1 170/4885 |
| US-20100075995-A1 | COMPOUNDS | IFNG, IRF3, IFNAR1 | TP53 300/4885CYP2C9 205/4885NFKB1 137/4885 |
| US-20220242866-A1 | PROCESS FOR THE PREPARATION OF 2-FLUOROADENINE | DCTD, AMPD2, CDA | TP53 2156/4885CYP2C9 400/4885NFKB1 2611/4885 |
| US-10919894-B2 | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions | HRH3, HRH4, HRH1 | TP53 2290/4885CYP2C9 1134/4885NFKB1 170/4885 |
| US-12391694-B2 | Process for the preparation of 2-fluoroadenine | DCTD, AMPD2, CDA | TP53 2156/4885CYP2C9 400/4885NFKB1 2611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.