Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11961091 | 0.85 | L3MBTL1 (0.51) | MAPK1KMT2AHTTMRGPRX4RAB9A | |
| SCHEMBL29944991 | 0.82 | SYK (0.52) | MRGPRX4RAB9AERBB2SYKEGFR | |
| SCHEMBL12524878 | 0.82 | MRGPRX4 (0.50) | MEN1MAPK1KMT2ATP53HTT | |
| SCHEMBL2702047 | 0.82 | SYK (0.52) | MRGPRX4RAB9AERBB2SYKEGFR | |
| SCHEMBL29945002 | 0.82 | SYK (0.52) | MRGPRX4RAB9AERBB2SYKEGFR | |
| SCHEMBL15932954 | 0.82 | ERBB2 (0.46) | MRGPRX4RAB9AATMERBB2SYK | |
| SCHEMBL15701536 | 0.82 | RXRA (0.50) | MRGPRX4RAB9AERBB2SYKEGFR | |
| SCHEMBL2760112 | 0.81 | SYK (0.59) | MEN1MAPK1KMT2ATP53HTT | |
| SCHEMBL17858634 | 0.78 | MRGPRX4 (0.55) | MEN1MAPK1KMT2ATP53HTT | |
| SCHEMBL27299184 | 0.78 | SYK (0.48) | MEN1MAPK1KMT2ATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2680850-B1 | ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE | NEWGEN THERAPEUTICS INC (US) | 2018-05-23 | — | — | EP | disclosed |