Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14433854 | 0.90 | SCN9A (0.60) | KMT2AMEN1RAB9ANAMPTCYP11B1 | |
| SCHEMBL1368828 | 0.85 | KIF11 (0.60) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL29793056 | 0.85 | KIF11 (0.60) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL4591751 | 0.83 | KMT2A (0.61) | KMT2AMEN1RAB9ANAMPTNPC1 | |
| SCHEMBL29845262 | 0.83 | KMT2A (0.61) | KMT2AMEN1RAB9ANAMPTNPC1 | |
| SCHEMBL20194707 | 0.81 | KIF11 (0.53) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL3954788 | 0.81 | ABL1 (0.58) | KMT2AMEN1NPC1MAPTLMNA | |
| SCHEMBL968252 | 0.80 | CYP11B1 (0.56) | KMT2AMEN1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL11875326 | 0.80 | MAPT (0.55) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL6431980 | 0.80 | RAB9A (0.62) | KMT2ARAB9ANAMPTNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137459-B1 | MORPHOLIN-PYRIDINE DERIVATIVES HAVING AFFINITY TO THE TAAR1 RECEPTOR | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |