Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13089147 | 0.87 | BRPF1 (0.62) | BRPF1BRD4CTSCSMN1; SMN2GAA | |
| SCHEMBL14552559 | 0.79 | CLK4 (0.46) | BRPF1SMN1; SMN2GAACYP11B1CYP11B2 | |
| SCHEMBL22050042 | 0.76 | BRPF1 (0.60) | BRPF1BRD4SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL20571810 | 0.76 | BRPF1 (0.60) | BRPF1BRD4CTSCSMN1; SMN2GAA | |
| SCHEMBL30668102 | 0.76 | BRPF1 (0.60) | BRPF1BRD4CTSCSMN1; SMN2GAA | |
| SCHEMBL7786930 | 0.76 | BRPF1 (0.60) | BRPF1BRD4CTSCSMN1; SMN2CYP1A2 | |
| SCHEMBL21013242 | 0.73 | TRIM24 (0.46) | CTSCTP53HPGDTRIM24 | |
| SCHEMBL10664661 | 0.73 | PDE3A (0.53) | BRPF1BRD4CTSCGAAHPGD | |
| SCHEMBL4476006 | 0.72 | BRPF1 (1.00) | BRPF1BRD4SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL30537994 | 0.72 | BRPF1 (1.00) | BRPF1BRD4SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323814-B1 | (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS | ASTRAZENECA AB (SE) | 2020-05-13 | — | — | EP | disclosed |
| EP-3323814-A1 | (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS | AstraZeneca AB (SE) | 2018-05-23 | — | — | EP | disclosed |