Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13089147 | 0.81 | BRPF1 (0.62) | BRPF1ALDH1A1SMN1; SMN2SRD5A1AKR1B1 | |
| SCHEMBL20571810 | 0.80 | BRPF1 (0.60) | BRPF1ALDH1A1SMN1; SMN2SRD5A1GABRA1 | |
| SCHEMBL22050042 | 0.80 | BRPF1 (0.60) | BRPF1ALDH1A1SMN1; SMN2SRD5A1GABRA1 | |
| SCHEMBL30668102 | 0.80 | BRPF1 (0.60) | BRPF1ALDH1A1SMN1; SMN2SRD5A1GABRA1 | |
| SCHEMBL4818630 | 0.78 | GABRA1 (0.45) | BRPF1SRD5A1GABRA1GABRG2GABRB3 | |
| SCHEMBL20172716 | 0.76 | BRPF1 (0.55) | BRPF1ALDH1A1SMN1; SMN2BRD4CYP1A2 | |
| SCHEMBL787636 | 0.75 | BRPF1 (0.39) | BRPF1ALDH1A1SRD5A1GABRA1GABRG2 | |
| SCHEMBL4476006 | 0.75 | BRPF1 (1.00) | BRPF1ALDH1A1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL30537994 | 0.75 | BRPF1 (1.00) | BRPF1ALDH1A1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL30480866 | 0.74 | BRPF1 (0.49) | BRPF1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251903-B1 | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist | COCENSYS, INC. | 2001-06-26 | — | — | US | disclosed |