Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22358676 | 0.88 | EIF4A3 (0.38) | EIF4A3FABP3FABP4MAPTNPC1 | |
| SCHEMBL24861762 | 0.85 | DPP4 (0.41) | MAPTNPC1RAB9ACA12CA1 | |
| SCHEMBL24861766 | 0.85 | DPP4 (0.41) | MAPTNPC1RAB9ACA12CA1 | |
| SCHEMBL21977601 | 0.85 | CA12 (0.39) | MAPTCA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL31472592 | 0.84 | DPP4 (0.40) | MAPTNPC1RAB9ACA12CA1 | |
| SCHEMBL30730119 | 0.83 | CA12 (0.38) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL1110779 | 0.79 | KMT2A (0.49) | MAPTNPC1RAB9ACA12CA1 | |
| SCHEMBL23657110 | 0.79 | EIF4A3 (0.41) | EIF4A3FABP3FABP4MAPTLMNA | |
| SCHEMBL19245855 | 0.78 | FABP3 (0.62) | FABP3FABP4MAPTNPC1RAB9A | |
| SCHEMBL522695 | 0.78 | KDM4E (0.57) | MAPTNPC1RAB9ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094927-A1 | ISOTOPICALLY-STABILIZED TETRONIMIDE COMPOUNDS | MIDWESTERN UNIVERSITY | 2021-04-01 | — | — | US | disclosed |
| US-10961211-B2 | Isotopically-stabilized tetronimide compounds | MIDWESTERN UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20200262804-A1 | Isotopically-Stabilized Tetronimide Compounds | MIDWESTERN UNIVERSITY | 2020-08-20 | — | — | US | disclosed |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961211-B2 | Isotopically-stabilized tetronimide compounds | ASPH, BACE1, DNPEP | EIF4A3 2596/4885FABP3 200/4885FABP4 564/4885 |
| US-20200262804-A1 | Isotopically-Stabilized Tetronimide Compounds | ASPH, BACE1, DNPEP | EIF4A3 2596/4885FABP3 200/4885FABP4 564/4885 |
| US-20210094927-A1 | ISOTOPICALLY-STABILIZED TETRONIMIDE COMPOUNDS | ASPH, BACE1, DNPEP | EIF4A3 2596/4885FABP3 200/4885FABP4 564/4885 |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | EIF4A3 1281/4885FABP3 530/4885FABP4 928/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | EIF4A3 1281/4885FABP3 530/4885FABP4 928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.