Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178571 | 0.86 | KDM4E (0.50) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL20173753 | 0.86 | KDM4E (0.50) | SLC2A1CYP11B1CYP11B2NPC1TP53 | |
| SCHEMBL15818525 | 0.80 | SLC2A1 (0.64) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL20118975 | 0.80 | SLC2A1 (0.54) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL20173748 | 0.80 | NR4A2 (0.51) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL20118979 | 0.78 | CYP46A1 (0.56) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL20178608 | 0.75 | MKNK1 (0.49) | CYP11B1CYP11B2CYP19A1NPC1MAPT | |
| SCHEMBL8700823 | 0.74 | CFTR (0.48) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL30118927 | 0.74 | KMT2A (0.61) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 | |
| SCHEMBL13435236 | 0.74 | KMT2A (0.61) | SLC2A1CFTRNR4A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | SLC2A1 845/4885CFTR 32/4885NR4A2 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.