Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052398 | 0.85 | PIK3CD (0.44) | LMNAHTTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2011286 | 0.83 | PIK3CD (0.40) | LMNAHTTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2013295 | 0.83 | PIK3CD (0.53) | LMNAHTTSMN1; SMN2MAPK1PIK3CD | |
| SCHEMBL2050742 | 0.81 | PIK3CD (0.42) | LMNAHTTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL20119349 | 0.79 | HTT (0.47) | LMNAHTTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2016174 | 0.77 | PIK3CD (0.54) | LMNASMN1; SMN2PIK3CDMAPTHSD17B10 | |
| SCHEMBL2016907 | 0.76 | KDM4E (0.44) | LMNAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4443103 | 0.75 | LMNA (0.40) | LMNAHTTSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2015901 | 0.74 | MAPK1 (0.48) | LMNAHTTSMN1; SMN2MAPK1PIK3CD | |
| SCHEMBL2010932 | 0.73 | KDM4E (0.43) | LMNAHTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |