Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.62 |
| ▸ | FABP1 | P07148 | 1/20 | 0.57 |
| ▸ | FABP6 | P51161 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31240672 | 0.77 | NOS2 (0.66) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL3175243 | 0.77 | NOS2 (1.00) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL7459147 | 0.77 | NOS2 (0.66) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL16041099 | 0.77 | NOS2 (0.66) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL14818957 | 0.75 | NOS2 (0.69) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL2015333 | 0.73 | HTR2C (0.47) | MEN1KMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29664808 | 0.73 | FABP1 (1.00) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL2230559 | 0.73 | FABP1 (1.00) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL5311875 | 0.73 | NOS2 (0.60) | NOS2FABP1FABP6ALDH1A1MEN1 | |
| SCHEMBL28966338 | 0.73 | NOS2 (0.65) | NOS2FABP1FABP6ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703961-B2 | Thiazole derivatives for the treatment of diseases such as cancer | MERCK PATENT GMBH (DE) | 2014-04-22 | — | — | US | disclosed |
| EP-2513071-A1 | THIAZOLE DERIVATIVES FOR TREATING DISEASES SUCH AS CANCER | Merck Patent GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-20120252759-A1 | THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKER HAFTING (DE) | 2012-10-04 | — | — | US | disclosed |
| WO-2011072779-A1 | THIAZOLE DERIVATIVES FOR TREATING DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252759-A1 | THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | RET, IGF1R, JAK2 | NOS2 2287/4885FABP1 2538/4885FABP6 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.