SCHEMBL20176570

SCHEMBL20176570

CN1c2ccccc2Cc2ccc(-c3ccc4c5ccccc5n(C)c4c3)cc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
GPR3 P46089 1/20 0.43
KIF11 P52732 1/20 0.41
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
HPGD P15428 5/20 0.39
KDM4E B2RXH2 5/20 0.39
ALDH1A1 P00352 4/20 0.39
MAPT P10636 4/20 0.39
LMNA P02545 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HSD17B10 Q99714 3/20 0.38
ATM Q13315 1/20 0.38
MEN1 O00255 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20747274 0.92 NPC1 (0.47) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL21032513 0.85 GPR3 (0.47) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL21032514 0.85 GPR3 (0.47) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL17904035 0.81 RXRA (0.48) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL19129975 0.81 RXRA (0.48) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL16373476 0.79 GPR3 (0.70) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL23847258 0.77 RXRA (0.48) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL12152361 0.77 ATM (0.49) NPC1RAB9AL3MBTL1POLBGAA
SCHEMBL12419781 0.76 GPR3 (0.64) NPC1RAB9AL3MBTL1RXRARXRB
SCHEMBL17904072 0.76 RXRA (0.42) NPC1RAB9AL3MBTL1RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11091452-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound ZEON CORPORATION (JP) 2021-08-17 US disclosed
US-10620352-B2 Circularly polarized light separating film and method for producing same ZEON CORPORATION (JP) 2020-04-14 US disclosed
US-20200048213-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND ZEON CORPORATION (JP) 2020-02-13 US disclosed
US-20180143361-A1 CIRCULARLY POLARIZED LIGHT SEPARATING FILM AND METHOD FOR PRODUCING SAME ZEON CORPORATION (JP) 2018-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200048213-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND PDE8A, MAPT, PLK4 NPC1 3200/4885RAB9A 3436/4885L3MBTL1 2549/4885
US-11091452-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound PDE8A, MAPT, PLK4 NPC1 3200/4885RAB9A 3436/4885L3MBTL1 2549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.