Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 11/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | POU2F2 | P09086 | 1/20 | 0.38 |
| ▸ | POU2F1 | P14859 | 1/20 | 0.38 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24135397 | 0.82 | KCNJ1 (0.47) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL24135356 | 0.82 | KCNJ1 (0.42) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL20168367 | 0.81 | KCNJ1 (0.52) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL30445170 | 0.81 | KCNJ1 (0.42) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL30444639 | 0.81 | KCNJ1 (0.52) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL20168335 | 0.81 | KCNJ1 (0.48) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL20168616 | 0.81 | KCNJ1 (0.42) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL30445113 | 0.81 | KCNJ1 (0.48) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL20168011 | 0.80 | KCNJ1 (0.42) | KCNJ1KCNH2ABCB11POU2F2POU2F1 | |
| SCHEMBL21266181 | 0.80 | KCNJ1 (0.42) | KCNJ1KCNH2ABCB11POU2F2POU2F1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3929194-A1 | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS | Bristol-Myers Squibb Company (US) | 2021-12-29 | — | — | EP | disclosed |
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |