Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19495078 | 0.83 | CCR5 (0.57) | TSHRSMN1; SMN2GLACCR5MEN1 | |
| SCHEMBL25866720 | 0.81 | ALDH1A1 (0.47) | TSHRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL18228501 | 0.77 | CCR5 (0.53) | TSHRSMN1; SMN2GLACCR5KMT2A | |
| SCHEMBL25866103 | 0.75 | TSHR (0.38) | TSHRSMN1; SMN2GLAMEN1KMT2A | |
| SCHEMBL12722194 | 0.73 | ALDH1A1 (0.48) | TSHRSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3973298 | 0.72 | TSHR (0.39) | TSHRSMN1; SMN2GLAMEN1KMT2A | |
| SCHEMBL17598478 | 0.71 | HTT (0.42) | TSHRCCR5MEN1KMT2AL3MBTL1 | |
| SCHEMBL25866610 | 0.71 | GAA (0.37) | TSHRSMN1; SMN2GLAMEN1KMT2A | |
| SCHEMBL22324638 | 0.71 | ALDH1A1 (0.46) | TSHRSMN1; SMN2GLAMEN1KMT2A | |
| SCHEMBL31288205 | 0.70 | KDM4E (0.56) | TSHRSMN1; SMN2GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |