Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NT5E | P21589 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176881 | 0.84 | TSHR (0.53) | KDM4EL3MBTL1HTTSMN1; SMN2RAB9A | |
| SCHEMBL20176883 | 0.82 | NAMPT (0.66) | HTTRAB9ANPC1PRKCILMNA | |
| SCHEMBL19774580 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1NT5ETYK2HTT | |
| SCHEMBL13947140 | 0.75 | KDM4E (0.81) | KDM4EL3MBTL1NT5ETYK2HTT | |
| SCHEMBL18027790 | 0.75 | KDM4E (0.64) | KDM4EL3MBTL1HTTSMN1; SMN2RAB9A | |
| SCHEMBL20176870 | 0.75 | NPC1 (0.62) | KDM4EL3MBTL1HTTSMN1; SMN2RAB9A | |
| SCHEMBL28675587 | 0.74 | KDM4E (0.49) | KDM4EL3MBTL1NT5ETYK2HTT | |
| SCHEMBL12017661 | 0.73 | ROCK2 (0.68) | KDM4EL3MBTL1NT5ETYK2HTT | |
| SCHEMBL12124452 | 0.73 | SMN1; SMN2 (0.57) | KDM4EL3MBTL1NT5ETYK2HTT | |
| SCHEMBL12017788 | 0.73 | NT5E (0.59) | KDM4EL3MBTL1NT5ETYK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2019-11-21 | — | — | US | disclosed |
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, ABL1, CNKSR1 | KDM4E 2267/4885L3MBTL1 593/4885NT5E 4009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.