SCHEMBL20177060

SCHEMBL20177060

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(-c4ccccc4)c(-n4c5ccccc5c5c4ccc4c6ccccc6n(-c6ccccc6)c45)c3)n2)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ATM Q13315 1/20 0.40
PTGER4 P35408 1/20 0.32
KMT2A Q03164 3/20 0.31
IL1R1 P14778 1/20 0.31
MEN1 O00255 2/20 0.30
ALDH1A1 P00352 2/20 0.30
MAPT P10636 2/20 0.30
HTT P42858 1/20 0.30
ABCG2 Q9UNQ0 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
HPGD P15428 1/20 0.30
JAK2 O60674 1/20 0.30
JAK3 P52333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21747099 0.96 KDM4E (0.38) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL18561384 0.94 KDM4E (0.36) L3MBTL1KDM4EATMPTGER4
SCHEMBL21746818 0.93 KDM4E (0.38) L3MBTL1KDM4EATMPTGER4RXFP1
SCHEMBL20177062 0.92 L3MBTL1 (0.36) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL22137211 0.92 ABCG2 (0.35) L3MBTL1KDM4EATMKMT2AMEN1
SCHEMBL23127800 0.91 L3MBTL1 (0.40) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL20177057 0.91 L3MBTL1 (0.42) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL26708570 0.90 L3MBTL1 (0.39) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL23127603 0.90 KDM4E (0.36) L3MBTL1KDM4EATMPTGER4KMT2A
SCHEMBL23347820 0.90 KDM4E (0.34) L3MBTL1KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10833276-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-11-10 US disclosed
US-20180145262-A1 Organic Electroluminescent Materials and Devices UNIVERSAL DISPLAY CORPORATION 2018-05-24 US disclosed
US-20180145262-A1 Organic Electroluminescent Materials and Devices UNIVERSAL DISPLAY CORPORATION 2018-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10833276-B2 Organic electroluminescent materials and devices OCIAD2, OCIAD1, TYR L3MBTL1 239/4885KDM4E 3046/4885ATM 590/4885
US-20180145262-A1 Organic Electroluminescent Materials and Devices OCIAD2, OCIAD1, TYR L3MBTL1 239/4885KDM4E 3046/4885ATM 590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.