Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.36 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.36 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12634883 | 0.99 | DRD5 (0.37) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018595 | 0.87 | DRD5 (0.39) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2018318 | 0.86 | SCNN1A (0.50) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL12635766 | 0.85 | SCNN1A (0.51) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2019947 | 0.85 | DRD5 (0.39) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2022260 | 0.84 | SCNN1A (0.38) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2024368 | 0.82 | ALDH1A1 (0.36) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| Iodide SCHEMBL2014693 | 0.82 | SCNN1A (0.37) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL2016440 | 0.81 | ALDH1A1 (0.37) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL12635937 | 0.81 | DRD5 (0.38) | DRD5SCNN1ASCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |