SCHEMBL20177512

SCHEMBL20177512

COc1cc(F)c([C@@H]2Cn3c(nc4ccccc43)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 17/20 0.59
FPR1 P21462 15/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177563 0.88 FPR2 (0.45) FPR2FPR1
SCHEMBL20411634 0.82 FPR2 (0.63) FPR2FPR1
SCHEMBL18264221 0.82 FPR2 (0.63) FPR2FPR1
SCHEMBL18264220 0.82 FPR2 (0.63) FPR2FPR1
SCHEMBL20177777 0.80 FPR2 (0.44) FPR2FPR1
SCHEMBL20177557 0.80 CA1 (0.42) FPR2FPR1
SCHEMBL20177795 0.80 FPR2 (0.60) FPR2FPR1
SCHEMBL18264291 0.79 FPR2 (0.64) FPR2FPR1
SCHEMBL18264289 0.79 FPR2 (0.64) FPR2FPR1
SCHEMBL18264245 0.78 FPR2 (0.60) FPR2FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed