SCHEMBL20177787

SCHEMBL20177787

COc1cc(F)c([C@H]2CC3=NOCCN3C2)c(F)c1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 2/20 0.46
PIK3CD O00329 5/20 0.33
PIK3CB P42338 4/20 0.33
PIK3CA P42336 4/20 0.33
FPR1 P21462 1/20 0.31
PRKDC P78527 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177526 1.00 FPR2 (0.46) FPR2PIK3CDPIK3CBPIK3CAFPR1
SCHEMBL20177602 0.85 FPR2 (0.34) FPR2
SCHEMBL20177622 0.84 FPR2 (0.34) FPR2
SCHEMBL20177551 0.82 FPR2 (0.35) FPR2
SCHEMBL20177487 0.73 FPR2 (0.58) FPR2FPR1
SCHEMBL20177546 0.71 KDM1A (0.36)
SCHEMBL20177747 0.71 KDM1A (0.36)
SCHEMBL18264295 0.68 FPR2 (0.75) FPR2FPR1
SCHEMBL18264293 0.68 FPR2 (0.75) FPR2FPR1
SCHEMBL18117769 0.66 PDE4A (0.50) FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed