SCHEMBL20177819

SCHEMBL20177819

O=C(O)[C@@H]1C(=O)NC[C@H]1c1c(F)cc(Br)cc1F

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 14/20 0.45
FPR1 P21462 11/20 0.42
F2RL1 P55085 4/20 0.36
HTR2A P28223 1/20 0.36
HRH1 P35367 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177699 0.88 FPR2 (0.42) FPR2FPR1
SCHEMBL28334900 0.87 FPR2 (0.40) FPR2FPR1
SCHEMBL20177892 0.85 FPR2 (0.45) FPR2FPR1
SCHEMBL20177775 0.83 FPR2 (0.49) FPR2FPR1
SCHEMBL16785462 0.82 FPR2 (0.55) FPR2FPR1
SCHEMBL16785357 0.82 FPR2 (0.39) FPR2FPR1
SCHEMBL18579252 0.82 FPR2 (0.55) FPR2FPR1
SCHEMBL20177644 0.82 KDM1A (0.47) FPR2FPR1F2RL1HTR2AHRH1
SCHEMBL22148275 0.82 FPR2 (0.57) FPR2FPR1
SCHEMBL16785414 0.82 FPR2 (0.57) FPR2FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed