SCHEMBL20177926

SCHEMBL20177926

COc1ccc(COC(=O)N[C@@H]2C(=O)NC[C@H]2c2cc(F)c(Cl)cc2F)cc1

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FPR1 P21462 16/20 0.51
FPR2 P25090 16/20 0.51
NAAA Q02083 4/20 0.45
ASAH1 Q13510 1/20 0.45
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177677 0.90 FPR1 (0.40) FPR1FPR2NAAAASAH1
SCHEMBL20177911 0.89 FPR2 (0.55) FPR1FPR2NAAAASAH1CYP3A4
SCHEMBL20177599 0.85 FPR2 (0.54) FPR1FPR2NAAAASAH1
SCHEMBL20177894 0.85 FPR2 (0.59) FPR1FPR2CYP3A4
SCHEMBL20177734 0.84 KCNQ2 (0.37) FPR1FPR2NAAAASAH1
SCHEMBL29434464 0.83 FPR2 (0.61) FPR1FPR2NAAA
SCHEMBL18106506 0.83 FPR2 (0.61) FPR1FPR2NAAA
SCHEMBL18106508 0.83 FPR2 (0.61) FPR1FPR2NAAA
SCHEMBL20177601 0.83 FPR2 (0.61) FPR1FPR2CYP3A4
SCHEMBL20177594 0.81 FPR2 (0.59) FPR1FPR2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed