Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | GAA | P10253 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408946 | 0.84 | POLB (1.00) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL15304543 | 0.80 | MEN1 (0.67) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL2201836 | 0.78 | MAPT (0.64) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL1260486 | 0.77 | MAPT (1.00) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL11864350 | 0.77 | KMT2A (0.68) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL13931158 | 0.77 | POLB (0.72) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL11726176 | 0.75 | KMT2A (0.61) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL13931170 | 0.75 | POLB (0.76) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL12384188 | 0.75 | POLB (0.76) | POLBKMT2AMAPTGAAKDM4E | |
| SCHEMBL13597571 | 0.75 | POLB (0.76) | POLBKMT2AMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981999-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-05-29 | — | — | US | disclosed |