Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11726176 | 0.94 | KMT2A (0.61) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL5461639 | 0.89 | MAPT (0.58) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL2604371 | 0.87 | MEN1 (0.74) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL3261412 | 0.86 | MAPT (0.66) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL11727835 | 0.86 | CD274 (0.66) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL14559413 | 0.86 | KMT2A (0.68) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL9380100 | 0.85 | KMT2A (0.76) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL9770297 | 0.84 | MAPT (0.60) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL5468412 | 0.84 | MAPT (0.59) | MAPTKMT2AGAAKDM4EMEN1 | |
| SCHEMBL5476546 | 0.81 | KMT2A (0.69) | MAPTKMT2AGAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977366-B2 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | CORNELL RESEARCH FOUNDATION, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977366-B2 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | CORNELL RESEARCH FOUNDATION, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977366-B2 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | CORNELL RESEARCH FOUNDATION, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20070021448-A1 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-25 | — | — | US | disclosed |
| US-20070021448-A1 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-25 | — | — | US | disclosed |
| US-20070021448-A1 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-25 | — | — | US | disclosed |
| WO-2006113236-A2 | NOVEL CHEMICAL INHIBITORS OF NEUTROPHIL ACTIVATION THROUGH THE SAC-DEPENDENT PATHWAY | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| WO-2005037213-A2 | ANTIINFLAMMATORY INHIBITORS OF RESPIRATORY BURST IN ADHERENT NEUTROPHILS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021448-A1 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation | MPO, MMP8, SERPINB1 | MAPT 4440/4885KMT2A 4421/4885GAA 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.