Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 4/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.58 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310149 | 0.84 | MRGPRX4 (0.49) | KAT6ASCN9AMRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL13141199 | 0.83 | MRGPRX4 (0.48) | KAT6ASCN9AMRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL20178601 | 0.83 | KAT6A (0.54) | KAT6ASCN9ASMYD3ALDH1A1GAA | |
| SCHEMBL12142424 | 0.83 | HDAC6 (0.59) | KAT6ASMYD3HSD17B10HDAC8HDAC6 | |
| SCHEMBL15672566 | 0.83 | ALDH1A1 (0.50) | KAT6ASCN9AMRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL20178637 | 0.81 | SMYD3 (0.55) | KAT6ASCN9ASMYD3HDAC8HDAC6 | |
| SCHEMBL3348416 | 0.80 | FLT1 (0.60) | KAT6AALDH1A1GAA | |
| SCHEMBL11818 | 0.80 | PLK1 (0.61) | KAT6ASMYD3MRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL11216517 | 0.80 | SMYD3 (0.60) | KAT6ASMYD3CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL7973340 | 0.80 | PLK1 (0.61) | SCN9AALDH1A1GAAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | KAT6A 2864/4885SCN9A 2939/4885SMYD3 3843/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | KAT6A 2864/4885SCN9A 2939/4885SMYD3 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.