Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 10/20 | 0.57 |
| ▸ | TACR3 | P29371 | 4/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017789 | 0.84 | TACR3 (0.57) | PANK3TACR3RIPK1 | |
| SCHEMBL2016712 | 0.80 | RET (0.48) | PANK3TACR3RIPK1GRM2RET | |
| SCHEMBL17687600 | 0.77 | PANK3 (0.48) | PANK3RIPK1JAK2JAK1JAK3 | |
| SCHEMBL24536328 | 0.74 | PANK3 (0.49) | PANK3RIPK1JAK2JAK1JAK3 | |
| SCHEMBL12683340 | 0.74 | CYP1A2 (0.52) | PANK3RIPK1 | |
| SCHEMBL19748509 | 0.73 | PANK3 (1.00) | PANK3 | |
| SCHEMBL21424030 | 0.73 | PANK3 (0.64) | PANK3 | |
| SCHEMBL23750439 | 0.73 | PANK3 (0.70) | PANK3 | |
| Hydrochloric Acid SCHEMBL17687632 | 0.72 | JAK2 (0.47) | PANK3RIPK1JAK2JAK1JAK3 | |
| SCHEMBL24536005 | 0.71 | PANK3 (0.47) | PANK3RIPK1JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513084-A1 | PYRROLIDINE DERIVATIVES AS NK - 3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073160-A1 | PYRROLIDINE DERIVATIVES AS NK - 3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |