Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.47 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023319 | 0.86 | RXRA (0.41) | KMT2AMEN1SMN1; SMN2NPC1CA1 | |
| SCHEMBL21578024 | 0.85 | ELANE (0.42) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 | |
| SCHEMBL21577995 | 0.82 | HTT (0.39) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 | |
| SCHEMBL20179151 | 0.82 | FOLH1 (0.44) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 | |
| SCHEMBL20179205 | 0.81 | FOLH1 (0.52) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 | |
| SCHEMBL20168306 | 0.79 | FOLH1 (0.42) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 | |
| SCHEMBL24023434 | 0.77 | HDAC3 (0.44) | LMNAMAPTSMN1; SMN2NPC1KDM4E | |
| SCHEMBL24023430 | 0.76 | ALDH1A1 (0.37) | KMT2ASMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL24023429 | 0.76 | SLC7A5 (0.45) | MAPTNPC1RAB9ACYP4F2CYP4A11 | |
| SCHEMBL1176935 | 0.76 | CA12 (0.61) | KMT2ACYP1A2MEN1SLC22A2TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |