Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 12/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179218 | 1.00 | LMNA (0.50) | LMNAGAAFOLH1HPGDMAPT | |
| SCHEMBL21577906 | 1.00 | LMNA (0.50) | LMNAGAAFOLH1HPGDMAPT | |
| SCHEMBL20179245 | 0.94 | FOLH1 (0.50) | LMNAGAAFOLH1 | |
| SCHEMBL20179122 | 0.94 | FOLH1 (0.50) | LMNAGAAFOLH1 | |
| SCHEMBL21570571 | 0.91 | LMNA (0.46) | LMNAGAAFOLH1HPGDMAPT | |
| SCHEMBL21578062 | 0.90 | LMNA (0.51) | LMNAGAAHPGDMAPTTDP1 | |
| SCHEMBL24023448 | 0.88 | LMNA (0.48) | LMNAGAAHPGDMAPTTDP1 | |
| SCHEMBL20168729 | 0.86 | FOLH1 (0.62) | LMNAFOLH1 | |
| SCHEMBL21578142 | 0.85 | LMNA (0.46) | LMNAGAAHPGDMAPTTDP1 | |
| SCHEMBL20168691 | 0.85 | FOLH1 (0.47) | LMNAGAAFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |