SCHEMBL20179548

SCHEMBL20179548

CC(C)(C)OC(=O)N1CCC2(CCCN2Cc2ccc(C(F)(F)F)cc2NCCC(C)(C)C(=O)OC(C)(C)C)CC1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 13/20 0.72
FAAH O00519 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20168491 0.87 MGLL (0.67) MGLLFAAH
SCHEMBL20166150 0.83 MGLL (1.00) MGLL
SCHEMBL29494566 0.83 MGLL (1.00) MGLL
SCHEMBL20182539 0.83 MGLL (0.80) MGLLFAAH
SCHEMBL20168504 0.83 MGLL (0.80) MGLLFAAH
SCHEMBL20182605 0.82 MGLL (0.56) MGLLFAAH
SCHEMBL19582699 0.82 MGLL (0.56) MGLLFAAH
SCHEMBL20769640 0.81 MGLL (0.58) MGLLFAAH
SCHEMBL20168709 0.81 MGLL (0.56) MGLLFAAH
SCHEMBL19582291 0.80 FAAH (0.64) MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3541820-B1 MAGL INHIBITORS H LUNDBECK AS (DK) 2023-07-05 EP disclosed
EP-3541820-B1 MAGL INHIBITORS H LUNDBECK AS (DK) 2023-07-05 EP disclosed
US-11691975-B2 MAGL inhibitors H. LUNDBECKA/S (DK) 2023-07-04 US disclosed
US-11691975-B2 MAGL inhibitors H. LUNDBECKA/S (DK) 2023-07-04 US disclosed
US-20220135563-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-05 US disclosed
US-20220135563-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-05 US disclosed
CN-110267962-B MAGL inhibitors H.隆德贝克有限公司 2022-04-01 CN disclosed
US-11059822-B2 MAGL inhibitors H. LUNDBECK A/S (DK) 2021-07-13 US disclosed
US-11059822-B2 MAGL inhibitors H. LUNDBECK A/S (DK) 2021-07-13 US disclosed
US-20200291023-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2020-09-17 US disclosed
US-20200291023-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2020-09-17 US disclosed
EP-3541820-A1 MAGL INHIBITORS Abide Therapeutics, Inc. (US) 2019-09-25 EP disclosed
WO-2018093949-A1 MAGL INHIBITORS ABIDE THERAPEUTICS, INC. (US) 2018-05-24 WO disclosed
WO-2018093949-A1 MAGL INHIBITORS ABIDE THERAPEUTICS, INC. (US) 2018-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11059822-B2 MAGL inhibitors MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-20220135563-A1 MAGL INHIBITORS MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-20200291023-A1 MAGL INHIBITORS MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-11691975-B2 MAGL inhibitors MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.