Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508161 | 0.80 | TSHR (0.32) | KDM4C | |
| SCHEMBL20227048 | 0.76 | — | — | |
| SCHEMBL20440766 | 0.73 | SIGMAR1 (0.32) | — | |
| SCHEMBL18492843 | 0.72 | — | — | |
| SCHEMBL22764114 | 0.71 | LMNA (0.36) | KDM4CLMNACNR1ADRA1ATDP1 | |
| SCHEMBL19403838 | 0.71 | — | — | |
| SCHEMBL6685198 | 0.71 | EPHX1 (0.33) | — | |
| SCHEMBL22686759 | 0.69 | EPHX1 (0.41) | KDM4E | |
| SCHEMBL28620145 | 0.67 | EPHX1 (0.43) | KDM4E | |
| SCHEMBL234960 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093695-A1 | FACTOR XIIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |