Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052089 | 0.92 | PIK3CD (0.48) | PIK3CDBCL2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL2012486 | 0.89 | PIK3CD (0.46) | PIK3CDBCL2HTTSMN1; SMN2MAPK1 | |
| Trifluoroacetic Acid SCHEMBL2052496 | 0.84 | PIK3CD (0.35) | PIK3CD | |
| SCHEMBL2016719 | 0.83 | PIK3CD (0.47) | PIK3CDBCL2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL2016865 | 0.82 | PIK3CD (0.56) | PIK3CDBCL2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL2012817 | 0.82 | PIK3CD (0.42) | PIK3CDBCL2 | |
| SCHEMBL2014148 | 0.81 | PIK3CD (0.47) | PIK3CDHTTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL2017994 | 0.79 | PIK3CD (0.55) | PIK3CDBCL2 | |
| SCHEMBL2051059 | 0.77 | PIK3CD (0.53) | PIK3CDBCL2LMNATSHRHSD17B10 | |
| SCHEMBL2050306 | 0.77 | PIK3CD (0.42) | PIK3CDBCL2HTTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |