Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 14/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CD79B | P40259 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180089 | 0.85 | NT5E (0.53) | NT5EADORA1ADORA3 | |
| SCHEMBL20180074 | 0.85 | NT5E (0.71) | NT5ECD79BADORA1ADORA3 | |
| SCHEMBL20168760 | 0.79 | NT5E (0.69) | NT5ECD79BADORA1ADORA3 | |
| SCHEMBL20180013 | 0.74 | ADORA3 (0.49) | NT5EADORA1ADORA3 | |
| SCHEMBL22866387 | 0.73 | NT5E (0.50) | NT5EADORA1ADORA3 | |
| SCHEMBL24078851 | 0.73 | NT5E (0.49) | NT5EADORA1ADORA3 | |
| SCHEMBL24078850 | 0.72 | NT5E (0.78) | NT5E | |
| SCHEMBL23345957 | 0.72 | NT5E (0.76) | NT5ECD79BADORA1ADORA3 | |
| SCHEMBL23345956 | 0.72 | NT5E (0.76) | NT5ECD79BADORA1ADORA3 | |
| SCHEMBL26283322 | 0.72 | NT5E (0.76) | NT5ECD79BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |