SCHEMBL20180122

SCHEMBL20180122

CC1(C)OB(c2cccc(Nc3ccccc3C(=N)c3ccncc3)c2)OC1(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.39
LPL P06858 4/20 0.33
LIPG Q9Y5X9 4/20 0.33
PDGFRB P09619 1/20 0.32
KDR P35968 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
SIRT2 Q8IXJ6 4/20 0.32
SIRT1 Q96EB6 3/20 0.32
KCNK3 O14649 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31
AKR1C3 P42330 1/20 0.31
AKR1C2 P52895 1/20 0.31
TAS2R14 Q9NYV8 1/20 0.31
AURKA O14965 1/20 0.30
NPC1 O15118 2/20 0.30
RAB9A P51151 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180263 0.91 EGFR (0.39) EGFRLPLLIPGPDGFRBKDR
SCHEMBL20615296 0.89 EGFR (0.35) EGFRLPLLIPGPDGFRBKDR
SCHEMBL20615277 0.84 MAPT (0.37) EGFRLPLLIPGPDGFRBKDR
SCHEMBL20180255 0.80 LIPG (0.44) EGFRLPLLIPGPDGFRBKDR
SCHEMBL20180123 0.78 EGFR (0.45) EGFRRXFP1SIRT2SIRT1PTGS1
SCHEMBL20180148 0.77 LIPG (0.38) EGFRLPLLIPGPDGFRBKDR
SCHEMBL20180251 0.77 LIPG (0.42) EGFRLPLLIPGPDGFRBKDR
SCHEMBL25491284 0.74 EGFR (0.42) EGFRLPLLIPGPDGFRBKDR
SCHEMBL18343191 0.74 KCNK3 (0.57) CA1CA2CA9KCNK3RAB9A
SCHEMBL20615350 0.74 LIPG (0.44) EGFRLPLLIPGPDGFRBKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed