Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20166487 | 1.00 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20166489 | 1.00 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL19773478 | 0.94 | DGAT2 (0.88) | DGAT2 | |
| SCHEMBL20166286 | 0.89 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20166284 | 0.89 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20167323 | 0.85 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20167879 | 0.85 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20167328 | 0.85 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL348128 | 0.79 | DGAT2 (0.66) | DGAT2 | |
| SCHEMBL20180470 | 0.77 | DGAT2 (1.00) | DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541376-B1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME LLC (US) | 2023-04-19 | — | — | EP | claimed |
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | claimed |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-09-12 | — | — | US | claimed |
| EP-3541376-B1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME LLC (US) | 2023-04-19 | — | — | EP | disclosed |
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-09-12 | — | — | US | disclosed |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2018093698-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | DGAT2, DGAT1, MOGAT2 | DGAT2 1/4885 |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | DGAT2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.