Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 7/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180730 | 0.84 | ALKBH5 (0.39) | WDR5SIRT6NOTUMDPP4HSD11B1 | |
| SCHEMBL23072821 | 0.81 | MAPT (0.41) | SIRT6KDM4EGAAMAPTMAPK1 | |
| SCHEMBL30565932 | 0.81 | MAPT (0.41) | SIRT6KDM4EGAAMAPTMAPK1 | |
| SCHEMBL20292786 | 0.81 | MAPT (0.41) | SIRT6KDM4EGAAMAPTMAPK1 | |
| SCHEMBL20180751 | 0.80 | GAA (0.38) | WDR5KDM4EGAAMAPTMAPK1 | |
| SCHEMBL15547228 | 0.79 | WDR5 (0.44) | WDR5NOTUM | |
| SCHEMBL20180514 | 0.78 | GAA (0.50) | KDM4EGAAMAPTMAPK1HTT | |
| SCHEMBL2832369 | 0.78 | PDK2 (0.48) | NOTUMDPP4KDM4EHTT | |
| SCHEMBL2832366 | 0.78 | PDK2 (0.48) | NOTUMDPP4KDM4EHTT | |
| SCHEMBL2965028 | 0.78 | PDK2 (0.48) | NOTUMDPP4KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |