Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | GFER | P55789 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12240582 | 0.80 | MAPT (0.69) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL4159588 | 0.80 | MAPT (0.55) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL188214 | 0.78 | ADRA2C (0.56) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL188069 | 0.78 | ADRA2C (0.56) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL1814699 | 0.78 | ADRA2C (0.56) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL854828 | 0.77 | MAPT (0.55) | MAPTGFERALDH1A1KDM4EGAA | |
| SCHEMBL81498 | 0.76 | ADRA2A (0.52) | ADRA2CADRB1 | |
| SCHEMBL10293570 | 0.76 | ADRA2A (0.52) | ADRA2CADRB1 | |
| SCHEMBL17898055 | 0.76 | ADRA2A (0.52) | ADRA2CADRB1 | |
| SCHEMBL2882914 | 0.74 | HRH3 (0.62) | MAPTGFERALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |